MOP : Design, Preparation, and Use for Palladium-Catalyzed Asymmetric Reactions
نویسندگان
چکیده
منابع مشابه
New Methods for the Synthesis of Vicinal Stereocenters: Palladium-Catalyzed Domino Reactions and Asymmetric Transfer Hydrogenation
In this thesis the synthesis of vicinal stereocenters is investigated in two distinct contexts, namely the construction of 3,3-disubstituted oxindoles and the synthesis of β-hydroxy-α-amino acids. Both scaffolds are prevalent in a range of natural products and biologically relevant compounds and, therefore, methods for their synthesis are of great import. First, the construction of 3,3-disubsti...
متن کاملPreparation of pyridine-3,4-diols, their crystal packing and their use as precursors for palladium-catalyzed cross-coupling reactions
A series of trifluoromethyl-substituted 3-alkoxypyridinol derivatives has been deprotected to furnish pyridine-3,4-diol derivatives in good yields. The X-ray crystal structure analysis proved that a 1:1 mixture of pyridine-3,4-diols and their pyridin-4-one tautomers exist in the solid state. Subsequent conversion into bis(perfluoroalkanesulfonate)s were smoothly achieved. The obtained compounds...
متن کاملPalladium-catalyzed asymmetric dearomatization of naphthalene derivatives.
An intramolecular enantioselective metal-catalyzed dearomatization reaction is described. This procedure allows the dearomatization of naphthalene derivatives through an electrophilic aromatic substitution-type reaction on a Pd(II) intermediate. The high yields and enantioselectivities achieved make this procedure a valuable method for synthetic chemists.
متن کاملPalladium-catalyzed asymmetric synthesis of allylic fluorides.
The enantioselective fluorination of readily available cyclic allylic chlorides with AgF has been accomplished using a Pd(0) catalyst and Trost bisphosphine ligand. The reactions proceed with unprecedented ease of operation for Pd-mediated nucleophilic fluorination, allowing access to highly enantioenriched cyclic allylic fluorides that bear diverse functional groups. Evidence that supports a m...
متن کاملPalladium-catalyzed asymmetric hydrogenation of functionalized ketones.
[reaction: see text]. A novel catalytic system for asymmetric hydrogenation of functionalized ketones has been developed using a Pd/bisphosphine complex as the catalyst in 2,2,2-trifluoroethanol. The reaction exhibits high enantioselectivity, and up to 92.2% ee was obtained.
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1998
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.118.6_193